دكتوراه
د. أمل يوسفان
- هيئة تدريسية
A Comprehensive Study on Nanoparticle Drug Delivery to the Brain: Application of Machine Learning Techniques
Molecular Pharmaceutics / 7 - ديسمبر - 2023
The delivery of drugs to specific target tissues and cells in the brain poses a significant challenge in brain therapeutics, primarily due to limited understanding of how nanoparticle (NP) properties influence drug biodistribution and off-target organ accumulation.
تحميل الملفInnovative Microencapsulation of Polymyxin B for Enhanced Antimicrobial Efficacy via Coated Spray Drying
Molecular Pharmaceutics / 19 - أكتوبر - 2024
This study aims to develop an innovative microencapsulation method for coated Polymyxin B, utilizing various polysaccharides such as hydroxypropyl β-cyclodextrin, alginate, and chitosan, implemented through a three-fluid nozzle (3FN) spray drying process. High-performance liquid chromatography (HPLC) analysis revealed that formulations with a high ratio of sugar cage, hydroxypropyl β-cyclodextrin (HPβCD), and sodium alginate (coded as ALGHCDHPLPM) resulted in a notable 16-fold increase in Polymyxin B recovery compared to chitosan microparticles. Morphological assessments using fluorescence labeling confirmed successful microparticle formation with core/shell structures.
تحميل الملفPolymeric nanoparticles loaded with vincristine and carbon dots for hepatocellular carcinoma therapy and imaging
scientific reports / 29 - أكتوبر - 2024
Chemotherapy for hepatoblastoma is limited by organ toxicity and poor outcomes, prompting the search for new, more effective treatments with minimal side effects. Vincristine sulfate, a potent chemotherapeutic, faces challenges due to P-glycoprotein-mediated resistance and its systemic toxicity. Nanoparticles offer a promising solution by improving pharmacokinetics, targeting tumor cells, thus reducing side effects. Moreover, the use of fluorescent nanomaterials is emerging in biomedical applications such as bioimaging, detection and therapies.
تحميل الملفPharmacy Education Science and Practice Conference 2025 Supplement Part B
Pharmaceutical Development and Technology / 13 - أبريل - 2025
This study aims to improve the solubility of a typical Biopharmaceutical Class II (ibuprofen), through application of amorphous solid dispersion (ASD) and manufacture of tuneable doses of the same through 3D printing of tablets
تحميل الملفDevelopment of pimozide spray dried lipid nanoparticles with enhanced targeting of non-small cell lung cancer
Journal of Drug Delivery Science and Technology / 27 - أبريل - 2025
This study aims to develop and evaluate the pimozide-loaded lipid nanoparticles (LNPs) designed for the targeted treatment of non-small cell lung cancer (NSCLC). Employing the microemulsion technique, three distinct types of LNPs were synthesized: solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), and liquid lipid carriers (LLC). These formulations were optimized in order to transform them into fine powders through spray drying. An assessment of their encapsulation efficiency (EE%), particle size, moisture sorption, surface morphology, and anti-proliferative activity against A549 lung cancer cells were evaluated.
تحميل الملف