Lymphatic filariasis is one of the most debilitating neglected tropical diseases (NTDs). It causes many infectious diseases leading to physical disabled, mental, social and financial losses. Since the year 2000, the World Health Organization (WHO) has launched a campaign to eliminate lymphatic filariasis, and significant achievements have been made in limiting the prevalence of disease in endemic regions. We will highlight certain points on Global Programme to Eliminate Lymphatic Filariasis (GPELF) and review the possibility of vaccine development against lymphatic filariasis in humans.