SARS-CoV-2 has caused global pandemic that resulted in a dramatic loss of human life worldwide. The first human case was reported in December 2019 in China, and while the first case in Syria was confirmed on March 2020. By July 1st, 2021, 25551 cases were reported in Syria with 1879 deaths. The most common symptoms of covid-19 are fever, dry cough, and shortness of breath. Some patients may endure from musculoskeletal, gastrointestinal and dermatologic symptoms. Many drugs (including antibiotics, corticosteroids, antiviral and Immunomodulatory drugs) have been evaluated and recommended to be used in COVID-19 treatment, resulting in clinical recovery.