Medullary carcinoma (MC) is a rare type of colon carcinoma that accounts for less than 1% of colorectal neoplasms. Morphologically, MC resembles many colorectal cancer (CRC) subtypes, mainly Neuroendocrine Carcinoma (NEC) due to exhibiting neuroendocrine features. In consequence, MC is exceedingly challenging to detect; numerous immunohistochemistry tests are required in order to distinguish it from the other subtypes of CRC.