This study is conducted to evaluate the antimicrobial activity of one extract of Styrax officinalis L envelopes of berries plant belonging to the Styracae family collected from the coastal area surrounding the city of Lattakia, Syria. Many efforts have been made to discover a new antimicrobial from a variety of sources such as micro- organisms, animals and plants. One such source is Folk medicine. Systematic screening of them may result in the discovery of a new effective compound. These extracts are prepared with polar solvent (methanol) by the steeping extraction method.