There are numerous generics of atenolol tablets available in Syria. The purpose of current study is to assess the physicochemical characters of four brands(A, B, C, D) of atenolol(50mg) tablets advertised in Syria and comparing these properties with reference drug(E). The physicochemical equivalence of brands of atenolol tablets were evaluated through performing hardness, friability, weight variation, content uniformity, and dissolution rate tests. The highest values of hardness are founded in tablets brand A while other brands are nearest in hardness to reference drug.