Objectives This study aims to evaluate the fatigue stress around custom-made all-on-4 implants system to find out which type of implants have a better performance under different graded multidirectional occlusal forces. Material and methods 3D normal and implanted models simulating the “All-on-4” concept were created and analyzed under three different conditions of occlusal loadings. Two types of static and fatigue were applied. Stress distribution was analyzed based on von Mises and Goodman theories in ANSYS environment in addition to the safety factor. Statistical tests were performed to assess the significance of the results as well as the reproducibility of the results.