Objective: the present study aimed at evaluation of antibacterial activity of wild local Asphodelus microcarpus and Asphodeline lutea against methicillin resistant Staphylococcus aureus (MRSA) isolates.. Methods: Antimicrobial activity of the crude extracts was evaluated against MRSA clinical isolates using agar wells diffusion. Determination of minimum inhibitory concentration( MIC)of methanolic extract of two studied plants was also performed using tetrazolium microplate assay